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UCSD Biological Automation Core

We offer access to our unique automated high-throughput Adaptive Laboratory Evolution (ALE) capabilities to both academic and industry through collaborative projects and fee for service work. Contact us for interest and see our Research and Publications pages for use cases.

ALE BOTS

Hardware for High-Throughput ALE drives efficient experimentation with consistent and process controlled selection.

A walk-up automated system for adaptive laboratory evolution experimentation and strain characterization.

  • Process-controlled modules to perform:
    • Constant-condition evolutions – ALEs
    • Dynamic-condition evolutions – FLIGHT ALEs
    • Tolerization evolutions – TALEs
    • Weaning evolutions – PALE ALEs
  • Characterization experiments with automated exometabolomic sampling – CHAR experiments
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BIOINFORMATICS SOFTWARE

Pipelines to organize samples and mutations, and perform meta-analyses across a secure database.

  • Pipelines to process whole genome sequencing reads, identify mutations using an ensemble approach, and output them to a database
  • A database infrastructure to store, search, and generate reports on mutations from ALE experiments

  ALEdb

RELIABLE AND PROVEN OPERATIONS

Experimental design, preparation, proven operation, regular maintenance, and troubleshooting enable efficient project completion and deliverables to collaborators and users.

  • Experiments are conducted by full-time professional staff dedicated to project execution.
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Contact us for academic and industrial collaborations