UC SAN DIEGO · DTU · FEIST LAB
EVOLUTION & PHENOTYPING BIOFOUNDRY
Start wherever your project needs us. Evolve strains in high-throuhgput on our ALEbots, characterize strains with automated phenotyping, pinpoint the mutations behind a phenotype, or build and simulate genome-scale models, as standalone services or one end-to-end campaign. Open to academic and industry partners, with engagement models to fit your project.
services we offer
Advanced automation and computational tools for biological discovery.
Leverage ALEbots to automate long-term adaptive laboratory evolution with precise environmental control, continuous monitoring, and high-frequency sampling. Cultures are passaged automatically at defined densities, enabling experiments that would be difficult or impractical to run manually.
Go from sequencing reads to annotated variants with our standardized resequencing pipelines. We detect point mutations, insertions and deletions, mobile-element movements, and structural rearrangements, then compare results against ALEdb to identify which mutations recur and likely matter.
Run growth phenotyping and condition screening on the same automated platforms that power our evolution campaigns. Measure growth, substrate uptake, and production rates across many strains and conditions in parallel, with every run tracked and recorded for consistent, comparable results.
Build, curate, and simulate genome-scale metabolic models of your organism. We integrate transcriptomic, proteomic, and metabolomic data to explain observed phenotypes, and apply strain-design algorithms to identify genetic interventions worth testing at the bench.
What is an Evolution & Phenotyping Biofoundry?
BUILT TO EVOLVE, MEASURE, AND MODEL STRAINS
Robotics, sequencing, and computation IN ONE PLACE
A biofoundry brings automation, measurement, and computation together so biological experiments can run more precisely and at a scale no bench can match. Ours combines our own ALEbots, refined over 15 years and now in their third generation, for long-term evolution and high-throughput strain characterization; standardized resequencing pipelines and ALEdb for mutation analysis; and genome-scale models for simulation and strain design. Each service can be used independently with any strain, or combined into a single campaign.
A biofoundry brings automation, measurement, and computation together so biological experiments can run more precisely and at a scale no bench can match. Ours combines our own ALEbots, refined over 15 years and now in their third generation, for long-term evolution and high-throughput strain characterization; standardized resequencing pipelines and ALEdb for mutation analysis; and genome-scale models for simulation and strain design. Each service can be used independently with any strain, or combined into a single campaign.
Platforms at ucsd
Platforms at dtu
how to work with us
Bring us a question or a problem. Let’s build the solution and experiment together.
Inside our biofoundry
HAVE AN EXPERIMENT IN MIND?
Build your next experiment with us.
Have a strain to characterize, mutations to explain, or an evolution experiment to run? Get in touch to see how our biofoundry can help, whether you need one service or a full campaign.
Member of the Global Biofoundry Alliance
We are a member of the Global Biofoundry Alliance, working with biofoundries around the world to advance automated biology and make these capabilities more accessible.
Lab Locations
San Diego, CA
University of California San Diego
Copenhagen, Denmark
Technical University of Denmark
Get in Touch
In accordance with applicable Federal and State law and University policy, the University of California does not discriminate, or grant preferences, on the basis of race, color, national origin, religion, sex, disability, and/or other protected categories. More information about Proposition 209 can be found here. More information about the University of California Anti-Discrimination Policy can be found here. Initiatives are open to all eligible members of the UC San Diego campus community and does not discriminate against, or grant preferential treatment to, any individual or group on the basis of race, color, national origin, religion, sex, disability, and/or other protected categories.
©2026 by Adam Feist and UC San Diego. All rights reserved.
Lab Locations
San Diego, CA
University of California San Diego
Copenhagen, Denmark
Technical University of Denmark
Get in Touch
In accordance with applicable Federal and State law and University policy, the University of California does not discriminate, or grant preferences, on the basis of race, color, national origin, religion, sex, disability, and/or other protected categories. More information about Proposition 209 can be found here. More information about the University of California Anti-Discrimination Policy can be found here. Initiatives are open to all eligible members of the UC San Diego campus community and does not discriminate against, or grant preferential treatment to, any individual or group on the basis of race, color, national origin, religion, sex, disability, and/or other protected categories.
©2026 by Adam Feist and UC San Diego. All rights reserved.